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Objective:To analyse the needs and framework development of an information platform on quality control of rehabilitation medicine based on ICF. Methods:According to the demanding of the information on quality control of rehabilitation medicine and the principle of the Internet Plus, this study discussed how to collect standardized data based on the classification and coding system of ICF, and how to implement the clinic standardized procedure and the clinical rehabilitation pathway on the information platform. Meanwhile, the index system on the information platform was also discussed to make data comparable among regions and countries. Results:This information platform should implement standardized procedure of diagnosis and treatment of rehabilitation medicine, based on the concept of ICF and ICD-11. The index system of the information platform should be compatible and open exchange. The structure of the information platform should use the framework, data standard, categories and coding of ICF. Conclusion:An information platform based on the ICF framework, terminology system and coding system can meet the needs of rehabilitation medical quality control, data collection and analysis.
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Objective:To apply World Health Organization Disability Assessment Schedule (WHODAS 2.0) as a tool to assess the functioning of the old patients after stroke. Methods:From August, 2018 to February, 2019, 107 old inpatients with stroke were divided into four groups according to the course of disease: ≤ 6 months, 7-12 months, 13-18 months and 19-24 months. They were assessed with WHODAS 2.0 and modified Barthel Index (MBI) at admission and discharge. Results:The scores of both MBI and total WHODAS 2.0 improved at discharge (t > 2.481, P < 0.001). WHODAS 2.0 total scores decreased with the course of disease (F = 3.444, P < 0.05), but no significant decrease was found in the domains of Getting Along, Life Activities and Participation (F < 2.410, P > 0.05). WHODAS 2.0 total scores negatively correlated with MBI score (r = -0.540, P < 0.001), except the scores of domains of Life Activities and Participation (r = 0.184, P > 0.05). Conclusion:WHODAS 2.0 can be used as a tool to assess and follow up the function and disability of old stroke patients.
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Objective To study the major chemical components from Inula helenium. Methods The compounds were separated and purifid by using a variety of chromatographic techniques including silica gel column chromatography, thin layer chromatography, and high performance liquid chromatography, and the structures of the compounds were verified by nuclear magnetic spectroscopy and literature data. Results A total of 22 compounds were separated from petroleum ether extract of I. helenium and identified separately as alantolactone (1), isoalantolactone (2), 4,4-dimethylsterols (3), 11αH,13-dihydroisoalantolactone (4), 11αH,13-dihydroalantolactone (5), 4(15)-epoxy-isoalantolactone (6), 5α,6α-epoxyalantolactone (7), alloalantolactone (8), isoalloalantolactone (9), friedelin (10), friedelinol (11), erythrodiol (12), β-sitosterol-glucopyranoside (13), lupeol acetate (14), lupeone (15), lupeol (16), δ-amyrin (17), lupeol palitate (18), 5,7,4'-trihydroxy-3',5'-dimethoxy flavane (19), (+)-syringaresinol (20), 3,5,3'-trihydroxy-6,7,4'-trimethoxy flavone (21), and 3,5,6,7,3'-hydroxy-4'-methoxy dihydroflavones (22). Conclusion Compounds 21 and 22 are isolated from this genus for the first time; Compounds 10-15, 17, and 18 are separated from the I. helenium for the first time. After antibacterial test, compounds 1, 2, 4, 5, 7-9 have strong inhibitory effects on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
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Objective: To study the chemical constituents from Gnaphalium affine and their anti-oxidative activities. Methods: Chemical constituents were isolated by column chromatography and semi-prepared HPLC, the structures were elucidated by spectral data and physicochemical properties. DPPH free radical scavenging activities of compounds 1,3-11, and 16 were determined. Results: Seventeen compounds were isolated and respectively identified as apigenin (1), dihydroapigenin (2), luteolin (3), chrysin (4), wogonin (5), stimasterol (6), β-sitosterol (7), ursolic acid (8), oleanolic acid (9), 19α-hydroxyl-oleanolic acid (10), 2α, 3α, 19α-trihydroxy-28-norurs-12ene (11), α-amyrin acetate (12), β-amyrin acetate (13), patriscabratine (14), aurantiamide acetate (15), 4'-hydroxydehydrokawain (16), and isovanillin (17). Compounds 1 and 3-5 had significant anti-oxidative activities. Conclusion: Compounds 2,4,5,11-15, and 17 are isolated from G. affine for the frist time.